HOME > Journal Search
Journal Search
Annals of Dermatology Journal
Condition Expression Quick Search
When you enter More than two words, please use ‘and , or’ operation by means of putting ‘,(Comma Mark)’ between each word.
If you use ‘Advanced Search’ , You can find specific result.

Annals of Dermatology 2011 Nov; 23(4): 529~535
Annals of Dermatology 2011 Nov; 23(4): 529~535

CD20 Positive T Cell Lymphoma Involvement of Skin
Ki Yeol Lee, M.D., Su Young Jeon, M.D., Jin Woo Hong, M.D., Young Hun Kim, M.D., Ki Hoon Song, M.D., Ki Ho Kim, M.D.
Department of Dermatology, College of Medicine, Dong-A University, Busan, Korea
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
CD20 positive T cell lymphoma is a rare condition that is associated with the coexpressions of CD20 and T cell markers, such as, CD3, CD5, or UCHL-1. Positivity for CD20 in this tumor represents an aberrant immunophenotype, but the presence of monoclonal T cell receptor (TCR) gene rearrangements and negativity for immunoglobulin heavy chain gene rearrangement indicate that this tumor is a T cell lymphoma. The majority of cases of CD20 positive T cell lymphoma have been reported as immature peripheral T cell lymphoma not otherwise specified. However, we believe that this disease is likely to be re-listed as a new disease entity after its pathogenesis has been elucidated and more cases have been evaluated. Here, we present a case of peripheral T cell lymphoma coexpressing CD20 and T cell markers with a demonstrable TCR gene rearrangement, in a patient who had been misdiagnosed as having B cell type lymphoma 4 years previously. We hypothesize that in this case initially circulating normal CD20+ T cell subsets underwent neoplastic transformation and CD20 positive T cell lymphoma subsequently developed in the lymph node, and then recurred in the skin due to systemic disease or metastasized from the nodal disease. (Ann Dermatol 23(4) 529∼535, 2011)
Annals of Dermatology 2011 Nov; 23(4): 529~535
Keyword : CD20, T cell lymphoma, T cell receptor gene arrangement
2008 ⓒ Copyright The Korean Dermatological Association. All Rights Reserved.
#303, Seocho Nasan Suite Office44, Seocho-daero 78-gil, Seocho-gu, Seoul 137-858, Korea
+Tel : 82-2-3473-0284 +Fax 82-2-3472-4203 Email: kda@derma.or.kr / Powered by INFOrang.co., Ltd