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Annals of Dermatology 2011 ; 23(3): 357~361
Annals of Dermatology 2011 ; 23(3): 357~361

Treatment of Keratoacanthoma with 5% Imiquimod Cream and Review of the Previous Report
Hye Chan Jeon, M.D., Mira Choi, M.D., Seung Hwan Paik, M.D., Chang Ho Ahn, M.D., Hyun Sun Park, M.D., Kwang Hyun Cho, M.D.
Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keratoacanthoma (KA) is a benign epidermal tumor, characterized by rapid and abundant growth, a tendency toward spontaneous regression and histopathologic similarity to squamous cell carcinoma (SCC). Because KA can be easily misdiagnosed as SCC, surgery is considered the treatment of choice. Recently, regression of KAs following application of 5% imiquimod cream (Aldara) has been reported. We present 4 cases of KA treated with topical imiquimod, applied 3 to 4 times a week. Obvious improvement was observed after 4 to 6 weeks of application and the lesions were almost cleared leaving scars after 9 to 11 weeks. These results show that topical imiquimod can be an effective option for the conservative management of KA as previously reported. We also suggest that lesions treated with imiquimod cream should be considered for biopsy to judge histopathological remission after 5 to 8 weeks of application to shorten the duration of the treatment. (Ann Dermatol 23(3) 357∼361, 2011)
Annals of Dermatology 2011 ; 23(3): 357~361
Keyword : Imiquimod, Keratoacanthoma
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