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Annals of Dermatology 2010 Nov; 22(4): 412~417
Annals of Dermatology 2010 Nov; 22(4): 412~417

Chemokine Receptor CCR3 Expression in Malignant Cutaneous Tumors
Yoon-Jin Lee, Ph.D., Dae-Hyun Kim, M.D.1, Sang-Han Lee, M.D., Hae-Seon Nam, M.D., Mi Ryung Roh, M.D.2, Moon-Kyun Cho, M.D.1
Molecular Cancer Research Center, College of Medicine, Soonchunhyang University, Cheonan, 1Department of Dermatology, College of Medicine, Soonchunhyang University, 2Department of Dermatology and the Cutaneous Biology Research Institute, College of Medicine, Yonsei University, Seoul, Korea
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: Chemokines and their receptors are important players in tumorigenesis by facilitating tumor proliferation and metastasis. Little is known about the possible function of chemokine receptors in relation to the development and progression of malignant cutaneous tumors. Objective: The aim of this study was to determine the chemokine receptor CCR3 expression pattern and the protein expression level in selected malignant cutaneous tumors. Methods: Four types of cell lines (G361, A431, SK-MEL-2, SK-MEL-24) were analyzed, using Western blotting, for the expression of CCR3 protein. Immunohistochemical staining for CCR3 was done on 36 skin cancer tissue samples that included 16 squamous cell carcinomas (SCCs), 16 basal cell carcinomas (BCCs), 16 malignant melanomas (MMs) and 6 normal tissue samples. Results: Western blot analysis showed that CCR3 protein was more expressed in the MM cell lines (G361, SK-MEL-2, SK-MEL-24) than that in the SCC cell line (A431), and the immunohistochemical analysis showed that CCR3 protein was overexpressed in MM and SCC, it was mildly expressed in BCC and it was hardly expressed in normal tissue. Conclusion: This study demonstrated via immunochemistry that CCR3 was more expressed in MM, followed by SCC and BCC. The existence of CCR3 protein may enhance the tumorigenic potential of malignant cutaneous tumors. (Ann Dermatol 22(4) 412∼417, 2010)
Annals of Dermatology 2010 Nov; 22(4): 412~417
Keyword : CC chemokine receptors, CCR3, Chemokine
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