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Annals of Dermatology 2009 May; 21(2): 185~188
Annals of Dermatology 2009 May; 21(2): 185~188

Progression from Acral Lentiginous Melanoma in situ to Invasive Acral Lentiginous Melanoma
Jung Min Bae, M.D., Hyung Ok Kim, M.D., Young Min Park, M.D.
Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Acral lentiginous melanoma (ALM) is the most common type of cutaneous melanoma in Asians. The very early stage of ALM demonstrates only a proliferation of a few atypical melanocytes within the epidermis, and has been termed ALM in situ. A 74-year-old male patient presented with a pigmented lesion on the left great toe for 12 years, which had initially showed only a few scattered hyperplastic atypical melanocytes without dermal invasion upon biopsy 5 years ago. This time however, rebiopsy of the lesion confirmed a diagnosis of ALM, stage IIIB. It could be inferred that the lesion had slowly progressed from ALM in situ to invasive ALM over a period of 12 years. Herein we report a case of ALM in situ which progressed to invasive ALM over a long period of time. We expect this report may assist physicians in early recognition and proper management of future cases of ALM in situ. (Ann Dermatol 21(2) 185∼188, 2009)
Annals of Dermatology 2009 May; 21(2): 185~188
Keyword : Acral lentiginous melanoma in situ
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